Incorporating Joint Embeddings into Goal-Oriented Dialogues with Multi-Task Learning

Attention-based encoder-decoder neural network models have recently shown promising results in goal-oriented dialogue systems. However, these models struggle to reason over and incorporate state-full knowledge while preserving their end-to-end text generation functionality. Since such models can greatly benefit from user intent and knowledge graph integration, in this paper we propose an RNN-based end-to-end encoder-decoder architecture which is trained with joint embeddings of the knowledge graph and the corpus as input. The model provides an additional integration of user intent along with text generation, trained with a multi-task learning paradigm along with an additional regularization technique to penalize generating the wrong entity as output. The model further incorporates a Knowledge Graph entity lookup during inference to guarantee the generated output is state-full based on the local knowledge graph provided. We finally evaluated the model using the BLEU score, empirical evaluation depicts that our proposed architecture can aid in the betterment of task-oriented dialogue system`s performance.Comment: The Semantic Web - 16th International Conference, ESWC 2019, Portoro\v{z}, Slovenia, June 2-6, 2019, Proceedings, page 225-23

A Retrospective Analysis of the Fake News Challenge Stance Detection Task

The 2017 Fake News Challenge Stage 1 (FNC-1) shared task addressed a stance classification task as a crucial first step towards detecting fake news. To date, there is no in-depth analysis paper to critically discuss FNC-1's experimental setup, reproduce the results, and draw conclusions for next-generation stance classification methods. In this paper, we provide such an in-depth analysis for the three top-performing systems. We first find that FNC-1's proposed evaluation metric favors the majority class, which can be easily classified, and thus overestimates the true discriminative power of the methods. Therefore, we propose a new F1-based metric yielding a changed system ranking. Next, we compare the features and architectures used, which leads to a novel feature-rich stacked LSTM model that performs on par with the best systems, but is superior in predicting minority classes. To understand the methods' ability to generalize, we derive a new dataset and perform both in-domain and cross-domain experiments. Our qualitative and quantitative study helps interpreting the original FNC-1 scores and understand which features help improving performance and why. Our new dataset and all source code used during the reproduction study are publicly available for future research

Impact of IRS: Four-years of entomological surveillance of the Indian Visceral Leishmaniases elimination programme

BACKGROUND In 2005, Bangladesh, India and Nepal agreed to eliminate visceral leishmaniasis (VL) as a public health problem. The approach to this was through improved case detection and treatment, and controlling transmission by the sand fly vector Phlebotomus argentipes, with indoor residual spraying (IRS) of insecticide. Initially, India applied DDT with stirrup pumps for IRS, however, this did not reduce transmission. After 2015 onwards, the pyrethroid alpha-cypermethrin was applied with compression pumps, and entomological surveillance was initiated in 2016. METHODS Eight sentinel sites were established in the Indian states of Bihar, Jharkhand and West Bengal. IRS coverage was monitored by household survey, quality of insecticide application was measured by HPLC, presence and abundance of the VL vector was monitored by CDC light traps, insecticide resistance was measured with WHO diagnostic assays and case incidence was determined from the VL case register KAMIS. RESULTS Complete treatment of houses with IRS increased across all sites from 57% in 2016 to 70% of houses in 2019, rising to >80% if partial house IRS coverage is included (except West Bengal). The quality of insecticide application has improved compared to previous studies, average doses of insecticide on filters papers ranged from 1.52 times the target dose of 25mg/m2 alpha-cypermethrin in 2019 to 1.67 times in 2018. Resistance to DDT has continued to increase, but the vector was not resistant to carbamates, organophosphates or pyrethroids. The annual and seasonal abundance of P. argentipes declined between 2016 to 2019 with an overall infection rate of 0.03%. This was associated with a decline in VL incidence for the blocks represented by the sentinel sites from 1.16 per 10,000 population in 2016 to 0.51 per 10,000 in 2019. CONCLUSION Through effective case detection and management reducing the infection reservoirs for P. argentipes in the human population combined with IRS keeping P. argentipes abundance and infectivity low has reduced VL transmission. This combination of effective case management and vector control has now brought India within reach of the VL elimination targets

Analysis of Enhanced OSPF for Routing Lightpaths in Optical Mesh Networks

We discuss enhancements to the OSPF protocol for routing and topology discovery in optical mesh networks. OSPF's opaque LSA mechanism is used to extend OSPF to disseminate optical resource related information through optical LSAs. Standard link-state database flooding mechanisms are used for distribution of optical LSAs. Each optical LSA carries optical resource information pertaining to a single optical link bundle between two adjacent OXCs, allowing for fine granularity changes in topology to be incorporated in path computation algorithms. OSPF packets are carried over a single IP control channel between adjacent OXCs. We analyze the performance of OSPF with optical extensions. Specifically, we compute control channel bandwidth used due to LSA updates

A Retrospective Analysis of the Fake News Challenge Stance-Detection Task

Denne studien baserer seg på en kvalitativ dokumentanalyse av Fagfornyelsen. Formålet har vært å belyse lytting som en muntlig ferdighet i et læreplanperspektiv. Vi har undersøkt hvordan Fagfornyelsen legger føringer for, og gir muligheter til arbeid med lytting i klasserommet. Spørsmålene som stilles er hvordan lyttebegrepet kommer til syne i kompetansemålene, og hvordan lyttebegrepet kan knyttes til verdier og prinsipper i overordnet del. Motivasjonen for å gjennomføre studien har vært å gi lytteferdigheten en større plass i forskningen, siden det er et felt som det ikke er forsket mye på. Gjennom funnene kommer det fram at lyttebegrepet enkelte ganger blir nevnt eksplisitt i kompetansemålene og overordnet del, men at begrepet i større grad kommer implisitt til syne gjennom for eksempel samtalebegrepet. Videre kan utvikling av muntlige ferdigheter og lytteferdigheten ses på som et mål i seg selv, men også som middel til å oppnå faglig forståelse. Av det siste funnet kommer det fram at lyttebegrepet kan knyttes til læreplanbegrepene kritisk tenkning og dybdelæring

Iron trafficking in patients with Indian Post kala-azar dermal leishmaniasis.

BACKGROUND:During infections involving intracellular pathogens, iron performs a double-edged function by providing the pathogen with nutrients, but also boosts the host's antimicrobial arsenal. Although the role of iron has been described in visceral leishmaniasis, information regarding its status in the dermal sequel, Post Kala-azar Dermal Leishmaniasis (PKDL) remains limited. Accordingly, this study aimed to establish the status of iron within monocytes/macrophages of PKDL cases. METHODOLOGY/PRINCIPAL FINDINGS:The intramonocytic labile iron pool (LIP), status of CD163 (hemoglobin-haptoglobin scavenging receptor) and CD71 (transferrin receptor, Tfr) were evaluated within CD14+ monocytes by flow cytometry, and soluble CD163 by ELISA. At the lesional sites, Fe3+ status was evaluated by Prussian blue staining, parasite load by qPCR, while the mRNA expression of Tfr (TfR1/CD71), CD163, divalent metal transporter-1 (DMT-1), Lipocalin-2 (Lcn-2), Heme-oxygenase-1 (HO-1), Ferritin, Natural resistance-associated macrophage protein (NRAMP-1) and Ferroportin (Fpn-1) was evaluated by droplet digital PCR. Circulating monocytes demonstrated elevated levels of CD71, CD163 and soluble CD163, which corroborated with an enhanced lesional mRNA expression of TfR, CD163, DMT1 and Lcn-2. Additionally, the LIP was raised along with an elevated mRNA expression of ferritin and HO-1, as also iron exporters NRAMP-1 and Fpn-1. CONCLUSIONS/SIGNIFICANCE:In monocytes/macrophages of PKDL cases, enhancement of the iron influx gateways (TfR, CD163, DMT-1 and Lcn-2) possibly accounted for the enhanced LIP. However, enhancement of the iron exporters (NRAMP-1 and Fpn-1) defied the classical Ferritinlow/Ferroportinhigh phenotype of alternatively activated macrophages. The creation of such a pro-parasitic environment suggests incorporation of chemotherapeutic strategies wherein the availability of iron to the parasite can be restricted